Hydrochlorothiazide: The most common signs and indications of overdose noticed in humans are Those people a result of electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from extreme diuresis.
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Nursing Mothers: It isn't identified whether irbesartan is excreted in human milk, but irbesartan or some metabolite of irbesartan is secreted at low concentration in the milk of lactating rats.
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Hydrochlorothiazide: Hydrochlorothiazide is a thiazide diuretic. Thiazides impact the renal tubular mechanisms of electrolyte reabsorption, straight escalating excretion of sodium and chloride in around equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide decreases plasma quantity, with consequent will increase in plasma renin action, will increase in aldosterone secretion, will increase in urinary potassium reduction, and decreases in serum potassium.
If digitalis has also been administered, hypokalemia might accentuate cardiac arrhythmias. The diploma to which hydrochlorothiazide is taken out by hemodialysis hasn't been proven. The oral LD50 of hydrochlorothiazide is greater than ten g/kg in the two mice and rats.
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Irbesartan: No knowledge can be found in regard to overdosage in people. Nonetheless, everyday doses of 900 mg for 8 months ended up perfectly tolerated. The probably manifestations of overdosage are predicted to be hypotension and tachycardia; bradycardia may additionally occur from overdose. Irbesartan just isn't taken out by hemodialysis.To get up-to-day specifics of the remedy of overdosage, a superb source is often a Accredited regional Poison Manage Middle. Telephone quantities of Qualified Poison Command Facilities are detailed while in the Doctors’ Desk Reference (PDR).
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